Hamster coagulation and serum proteins in rat recipients of hamster xenografts.

The antigenicity of serum proteins and their role in xenograft rejection.

I T HAS been reported previously that following xenotransplantation. liver secretes proteins of donor origin into the serum of xenograft recipients. thus allowing them to retain their species-specificity. I The persistence and the function of hamster xenoproteins in long-surviving hamster --> rat liver transplant recipients has already been well established. ~ In the present study, we have exte...

Donor species complement after liver xenotransplantation. The mechanism of protection from hyperacute rejection.

Hamster hearts transplanted into stable rat recipients of hamster livers (OLT rats) were hyperacutely rejected after transfer with unaltered rat antihamster hyperimmune serum (HS). This was followed by immediate liver xenograft rejection in 4 of 5 rats. In contrast, simple heat inactivation of the rat HS resulted in prolonged survival of hamster hearts to 25 days without deterioration effect in...

Distribution of the serum proteins of Syrian hamster as revealed by Starch gel electrophoresis

Functional cooperation of xenoproteins after hamster-to-rat liver transplantation: With particular reference to hamster C3 and secretory component for rat IgA.

Long-term survival after hamster-to-rat liver xenotransplantation has provided the opportunity to study the posttransplantation source of major serum proteins and the functional consequences of several different receptor-ligand interactions, where one or the other is a xenogeneic protein. We report here that serum albumin, α-1-antitrypsin, complement component 3, and other acute phase reactants...

Complement and target cells belong to the same species after liver xenografting: protection from hyperacute rejection.

L IVER xenografting implies that most of the complement (C) in the recipients will be produced by the graft. It is known that membrane-bound proteins have the property of homologous restriction; ie. they inhibit MACmediated lysis only when the terminal C components are from the same species as the cells on which these proteins are expressed. I To test the hypothesis that this could be a mechani...